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Bible Hub Commentary Isaiah 53:4
https://biblehub.com/commentaries/isaiah/53-4.htm
MacLaren's Expositions
Isaiah-THE SUFFERING SERVANT II - Isaiah 53:4 - Isaiah 53:6.

The note struck lightly in the close of the preceding paragraph becomes dominant here. One notes the accumulation of expressions for suffering, crowded into these verses-griefs, sorrows, wounded, bruised, smitten, chastisement, stripes. One notes that the cause of all this multiform infliction is given with like emphasis of reiteration-our griefs, our sorrows, and that these afflictions are invested with a still more tragic and mysterious aspect, by being traced to our transgressions, our iniquities. Finally, the deepest word of all is spoken when the whole mystery of the servant’s sufferings is referred to Jehovah’s making the universal iniquity to lie, like a crushing burden, on Him.

I. The Burdened Servant.

It is to be kept in view that the ‘griefs’ which the servant is here described as bearing are literally ‘sicknesses,’ and that, similarly, the ‘sorrows’ may be diseases. Matthew in his quotation of the verse {Matthew 8:17} takes the words to refer to bodily ailments, and finds their ‘fulfilment’ in Christ’s miracles of healing. And that interpretation is part of the whole truth, for Hebrew thought drew no such sharp line of distinction between diseases of the body and those of the soul as we are accustomed to draw. All sickness was taken to be the consequence of sin, and the intimate connection between the two was, as it were, set forth for all forms of bodily disease by the elaborate treatment prescribed for leprosy, as pre-eminently fitted to stand as type of the whole. But the fulfilment through the miracles is but a parable of the deeper fulfilment in regard to the more virulent and deadly diseases of the soul. Sin is the sickness, as it is also the grief, which most afflicts humanity. Of the two words expressing the Servant’s taking their burden on His shoulders, the former implies not only the taking of it but the bearing of it away, and the latter emphasises the weight of the load.