“Then the sixth angel sounded: And I heard a voice from the four horns of the golden altar which is before God, saying to the sixth angel who had the trumpet, “Release the four angels who are bound at the great river Euphrates.” So the four angels, who had been prepared for the hour and day and month and year, were released to kill a third of mankind.” Revelation 9:13-15 nkjv
We all know that God is faithful and prevents the certain events to be held until the end, to make sure every given opportunity is given to mankind to repent. This was the case in Noah's Ark, Sodom and Gomorrah, and also coming of our Lord Jesus Christ on the cross, seeking patiently for all to turn back to him. It seems like that the four angels with great power will be released at the right moment of time, to serve the purpose of God, God’s judgement on those who deny him with death. Since these angels were bound, possibly, we could conclude that there are like the fallen angels. But, they will be used to punish mankind. We need to remember that God is patient, but he is just. If we forget that God is holy, then, it’s hard to see that God's judgement is just.